Sunday, August 5, 2007

California DUI Drug & Alcohol Interaction

California DUI - Drugs Attorney news

When one mixes prescription medication with alcohol, it may be time for a California DUI / Drunk Driving Attorney to reach for Donald J. Bartell / Anne D. Imobstersteg in Attacking and Defending Drunk Driving Tests' California DUI Lawyer book, including under section 2:41 [Factors That Affect Absorption] First Pass Metabolism: Ibuprofen, Ranitidine, Cimetidine, and Aspirin.

The understanding of drug-alcohol interactions is important for the California DUI Attorney's full evaluation of a California DUI .

"First-pass" metabolism generally refers to the metabolism of alcohol that occurs before alcohol actually reaches the blood stream.

This phenomenon is one reason why alcohol, when consumed with food, exhibits a lower alcohol curve in addition to a delayed peak.

Here are two sample quotes from drug descriptions.

http://www.rxlist.com/cgi/generic/verapsr_ad.htm

Alcohol: Verapamil has been found to inhibit ethanol
elimination significantly, resulting in elevated blood
ethanol concentrations that may prolong the
intoxicating effects of alcohol (see CLINICAL
PHARMACOLOGY: Pharmacokinetics and Metabolism).


http://www.rxlist.com/cgi/generic/verapsr_cp.htm#CP

In ten healthy males, administration of oral verapamil
(80 mg every 8 hours for 6 days) and a single oral dose
of ethanol (0.8 g/kg) resulted in a 17% increase in
mean peak ethanol concentrations (106.45 ± 21.40 to
124.23 ± 24.74 mg·hr/dl) compared to placebo. The area
under the blood ethanol concentration versus time curve
(AUC over 12 hours) increased by 30% (365.67 ± 93.52 to
475.07 ± 97.24 mg·hr/dl). Verapamil AUCs were
positively correlated (r=0.71) to increased ethanol
blood AUC values (see DRUG INTERACTIONS) .


San Diego California DUI Lawyer Rick Mueller, a San Diego California Drunk Driving / DWI Defense Attorney handling San Diego California DUI & DMV cases, shows how a San Diego California DUI Lawyer will help you. http://www.sandiegodrunkdrivingattorney.net

Donald Bartell can be reached at http://www.dui-california.com/don_bartel.html - (951) 788-2230.

Related California DUI Lawyer information can be found at
http://www.sandiegoduilawyer.com/2007/08/am-i-san-diego-dui-if-i-fell-asleep-or.html and http://www.sandiegodrunkdrivingattorney.net/Sleep-Driving.html .

California - San Diego DUI Help Blog http://www.sandiegoduihelp.com/duiblog/index.html